Concentration of antibacterial agents in rat bone

✍ Scribed by J. S. Papadopulos; Ch. Karageorgiou; J. Papadatos; St. Papavassiliou; D. D. Varonos

• Book ID: 104751562
• Publisher: Springer
• Year: 1981
• Tongue: English
• Weight: 251 KB
• Volume: 99
• Category: Article
• ISSN: 1434-3916
• DOI: 10.1007/bf00389745

✦ Synopsis

The concentrations of Gentamicin, Ampicillin and Cephaloridine in thigh rat bone were studied. Measurements were done after a 24 h administration for 3 different times.

Measurable quantities in the bone for the three antibiotics were detected The best levels in relation with the M I C of 4 microorganisms occurred in Cephaloridine (and in measurements of serum and bone (Jtg/g).

The concentration in the serum does not represent concentration in the bone The most convinient parity was for Cephaloridine.

The elimination of the drug in the bone was impressive after 2 h The slower fall occurred in Cephaloridine.

Ampicillin had the same level in 4 and 6 h. Gentamicin and Cephaloridine had failed to present measurable quantities in some of the animals of the last measurement.