Concentration adjustment of spot samples in analysis of urinary xenobiotic metabolites

✍ Scribed by Andrea Trevisan

• Book ID: 101440267
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 352 KB
• Volume: 17
• Category: Article
• ISSN: 0271-3586
• DOI: 10.1002/ajim.4700170508

✦ Synopsis

The reliability of the adjustment for the reduction of concentration-dilution effects in urinalysis of spot specimens was evaluated; 95.4 % of spot specimens showed a creatinine concentration between 0.5 and 3 g/liter, whereas 59.8% showed a specific gravity between 1.010 and 1.030. Only 6% of the specimens exceeded the specific gravity of I .035 corresponding to a creatinine concentration of 3 giliter. Therefore, an acceptable value for specific gravity in spot specimens of 1.035 is proposed. Although either specific gravity or creatinine provides a reliable mean of adjustment, creatinine is preferred because it has fewer physiological confounding factors.