## Abstract Despite the importance of gene‐environment (G×E) interactions in the etiology of common diseases, little work has been done to develop methods for detecting these types of interactions in genome‐wide association study data. This was the focus of Genetic Analysis Workshop 16 Group 10 con
Concealed effects of gene–environment interactions in genome-wide association
✍ Scribed by Adam E. Handel; Alexander J. Williamson; Sreeram V. Ramagopalan
- Book ID
- 113809811
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- English
- Weight
- 505 KB
- Volume
- 1
- Category
- Article
- ISSN
- 2211-0348
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Many complex diseases are likely to be a result of the interplay of genes and environmental exposures. The standard analysis in a genome-wide association study (GWAS) scans for main effects and ignores the potentially useful information in the available exposure data. Two recently proposed methods t
## Abstract In this paper we investigate the power to identify gene × gene interactions in genome‐wide association studies. In our analysis we focus on two‐stage analyses: analyses in which we only test for interactions between single nucleotide polymorphisms that show some marginal effect. We give