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Concanavalin A induces an intraluminal alkalinization of thymocyte membrane vesicles

✍ Scribed by Ross B. Mikkelsen; Rupert Schmidt-Ullrich; Donald F. H. Wallach

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 504 KB
Volume: 102
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041020203

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✦ Synopsis

Abstract

Weak acid distribution methods demonstrate that mitogenic levels of concanavalin A induce an intravesicular alkalinization of isolated thymocyte membrane vesicles. Experiments with chemical reagents that crosslink the high affinity concanavalin A receptor and extensive correlation with known cellular events suggest that a “membrane Bohr effect” may participate in the initiation of mitogenesis.

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Cooperative binding of concanavalin a to thymocyte membrane vesicles augments uptake of α-aminoisobutyrate

✍ Rupert Schmidt-Ullrich; Nathan D. Mann; Donald F. H. Wallach 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB

## Abstract (1) Membrane vesicles from rabbit thymocytes accumulate α‐aminoisobutyrate in the presence of 0.1 M NaCl. Uptake is 1/2 maximal after about 2 min and reaches a plateau value (61 pmoles/mg protein) after 30 min. (2) Up to 25 μg concanavalin A/ml, binding of the lectin describes a sigmoid