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Comutagenic Effect of Norharman and Harman with 2-acetylaminofluorene Derivatives

✍ Scribed by Kazuo Umezawa, Atsuko Shirai, Taijiro Matsushima and Takashi Sugimura


Book ID
123654934
Publisher
National Academy of Sciences
Year
1978
Tongue
English
Weight
401 KB
Volume
75
Category
Article
ISSN
0027-8424

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Monolayers of rat hepatocytes metabolize 0.25 mM 2acetylaminofluorene (AA F) to various ether-extractable, watersoluble as well as covalently bound products. The major ether-extractable metabolite formed is 2-aminofluorene (AF), followed by 7-OH-AAF and 9-OH-AAF. Pretreatment of rats with the induce