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COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents

✍ Scribed by Subirós-Funosas, Ramon; Nieto-Rodriguez, Lidia; Jensen, Knud J.; Albericio, Fernando


Book ID
120369701
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
236 KB
Volume
19
Category
Article
ISSN
1075-2617

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Disulfide interchange in DMSO, during amide formation by prior thiol capture is reduced to less than 3% at low concentrations (<lo M) of substrate in the absence of air and light, and in the presence of 2.5 to 10 mole % AgNo3T The rate and selectivity of the exchange process were assessed by reactin