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COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia

✍ Scribed by Alessandro Bertolino; Grazia Caforio; Giuseppe Blasi; Antonio Rampino; Lorenzo Sinibaldi; Sophia Douzgou; Marcello Nardini; Daniel R. Weinberger; Bruno Dallapiccola


Book ID
119363183
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
243 KB
Volume
95
Category
Article
ISSN
0920-9964

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## Abstract Negative symptoms are considered the most debilitating and refractory aspect of schizophrenia, being associated with poor social, occupational and global outcomes. Conventional antipsychotics have limited efficacy against these symptoms and poor tolerability profiles. Atypical antipsych