COMT inhibition and Parkinson's disease
✍ Scribed by E. Dorflinger; G. Magni; F. Hoffmann
- Book ID
- 118600366
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 385 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0924-977X
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## Abstract The effect of selegiline (L‐deprenyl) on plasma catecholamines, clinical response, and drug tolerability was studied in 13 patients with Parkinson's disease (PD) treated with L‐Dopa/benserazide and entacapone, a peripheral catechol‐__O__‐methyltransferase (COMT) inhibitor, in a placebo‐
Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder ha