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Computerized calculation of in vitro generation of ATP and creatine phosphate induced by respiration in human muscle mitochondria

✍ Scribed by Johan C. Fischer; Wim Ruitenbeek; Ad M. Stadhouders; J.M.Frans Trijbels; Rob C.A. Sengers; Antoon J.M. Janssen; Jacques H. Veerkamp; Réne J.M. Bindels

Book ID
103051248
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
784 KB
Volume
15
Category
Article
ISSN
0010-4825

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✦ Synopsis

A computer program is presented which calculates the action of adenylate kinase and creatine kinase during the process of adenosine-5'-triphosphate generation by the mitochondria in human skeletal muscle 600 x g supernatants. The results show that the mass action ratios of the two kinase reactions are not influenced by incubation time or decreased rate of oxidative phosphorylation as a result of mitochondrial dysfunction. The program is useful for establishing optimum initial adenosine-5'-diphosphate and creatine concentrations in the assay medium. Computerized calculation Mitochondria Human skeletal muscle Oxidative phosphorylation Creatine kinase Adenylate kinase Assay development

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