𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Computer simulation of the conformational behaviour of angiotensinogen (6–13) renin substrate

✍ Scribed by M. Benkoulouche; M. Cotrait; B. Maigret

Publisher
Springer Netherlands
Year
1992
Tongue
English
Weight
603 KB
Volume
6
Category
Article
ISSN
0920-654X

No coin nor oath required. For personal study only.

✦ Synopsis

The conformational behaviour of the biologically active angiotensinogen (6-13) fragment has been investigated by computer simulations. A large sample of conformers has been generated using the Monte-Carlo procedure, then analysed using classification and partition methods. Seven families can describe the conformational distribution. About 40% of conformers are fully extended, 28% are folded at the C-terminal His 6-Pro7-PheS-His 9 level and the others are folded at different levels. The study highlights the extreme flexibility of the angiotensinogen fragment.

📜 SIMILAR VOLUMES

Computational simulations of the conform
Computational simulations of the conformational behaviour of the adhesive proteins RGDS fragment
✍ M. Cotrait; M. Kreissler; J. Hoflack; J.-M. Lehn; B. Maigret 📂 Article 📅 1992 🏛 Springer Netherlands 🌐 English ⚖ 928 KB

Many adhesive proteins present in extracellular matrices and in blood contain the tetrapeptide sequence -Arg-Gly-Asp-Ser-(or RGDS) at their cell recognition site. Since this sequence, or similar ones, was found in many proteins involved in major biological mechanisms, conformational investigations w