✦ LIBER ✦

Computer simulation for large scale bioprocess design

✍ Scribed by S.A Rouf; P.L Douglas; M Moo-Young; J.M Scharer

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 87 KB
Volume: 8
Category: Article
ISSN: 1369-703X
DOI: 10.1016/s1369-703x(01)00112-7

No coin nor oath required. For personal study only.

✦ Synopsis

Two bioprocess simulators, Aspen BPS TM and SuperPro Designer ® , were used to simulate and compare two flowsheets for production of tissue plasminogen activator (t-PA) from Chinese hamster ovary (CHO) cells. The flowsheets were designed to compare the economics of using serum and serum-free medium in the bioreactor. The base case flowsheet used a medium with 10% serum while the alternative flowsheet used a serum-free medium.

Affinity chromatography was the major step in the downstream processing of the base case flowsheet. The alternate flowsheet was designed for two-step cell culture growth and production. Ion-exchange chromatography was considered sufficient for purification of the low protein medium for this case. At a price of US$ 25/l for serum-free medium, the alternate flowsheet was found to have an return on investment (ROI), of 115% compared to 65% for the base case flowsheet.

📜 SIMILAR VOLUMES

Large-scale computer simulation and syst

Large-scale computer simulation and systems design of computer-integrated manufacturing

✍ Bin Wu 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 988 KB

Large-scale urbulence simulation on the

Large-scale urbulence simulation on the Navier-Stokes computer

✍ M.E. Hayder; W.S. Flannery; M.G. Littman; D.M. Nosenchuck; S.A. Orszag 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 743 KB

Computer simulation of isothermal fluidi

Computer simulation of isothermal fluidization in large-scale laboratory rigs

✍ D. W. Richner; T. Minoura; J. W. Pritchett; T. R. Blake 📂 Article 📅 1990 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 876 KB

Parallelization of a large-scale computa

Parallelization of a large-scale computational earthquake simulation program

✍ K. F. Tiampo; J. B. Rundle; P. Hopper; J. Sá Martins; S. Gross; S. McGinnis 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB

Large scale particle simulations in a vi

Large scale particle simulations in a virtual memory computer

✍ P.C. Gray; J.S. Wagner; T. Tajima; R. Million 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 957 KB

Virtual memory computers are capable of executing large-scale particle simulations even when the memory requirements exceed the computer core size. The required address space is automatically mapped onto slow disc memory by the operating system. When the simulation size is very large, frequent rando

Atomic Computer Simulation: Large Scale

Atomic Computer Simulation: Large Scale Calculations of Defect Properties by Empirical Potentials

✍ A. Serra 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB 👁 2 views

This paper is aimed at introducing computer simulation of extended defects in crystalline materials by means of empirical potentials. In this context we understand by large scale calculations those related to a number of atoms from 10 3 to 10 6 and/or a time scale of few nanoseconds (10 2 -10 4 ps)