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Computer prediction of potential immunogenic determinants from protein amino acid sequence

✍ Scribed by Viktor Krchňák; Otakar Mach; Antonín Malý

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
758 KB
Volume
165
Category
Article
ISSN
0003-2697

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✦ Synopsis

In proteins, immunogenic determinants that can induce protein-reactive antipeptide antibodies reside mostly in those parts of the molecule that have a high tendency to form &turns. A program for an IBM personal computer which predicts protein immunogenic determinants is described. The program predicts potential immunogenic determinants from protein amino acid sequences according to a Chou-Fasman-based probability of a B-turn occurrence, p > 1.5 X lo-" (P. Y. Chou and G. D. Fasman, 1978, Adv. Enzymol. 47,46-148). Oncopeptides (whose efficacy in generating protein-reactive antipeptide antibodies has been described) with a p-turn probability of p > 1.5 X 10m4 elicited antipeptide antibodies that reacted with the parent oncoprotein at a rate of 96%, thus showing a surprisingly good correlation between the tendency to form a &turn and the protein reactivity of antipeptide antibodies. Potential immunogenic determinants were predicted on myohemerythrin and myoglobin. o 1987 Academic RCSS, IIIC.

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