Computer Methods, Imaging and Visualization in Biomechanics and Biomedical Engineering: Selected Papers from the 16th International Symposium CMBBE ... in Computational Vision and Biomechanics, 36)

✍ Scribed by Gerard A. Ateshian (editor), Kristin M. Myers (editor), João Manuel R. S. Tavares (editor)

• Publisher: Springer
• Year: 2020
• Tongue: English
• Leaves: 672
• Category: Library

✦ Synopsis

This book gathers selected, extended and revised contributions to the 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, and the 4th Conference on Imaging and Visualization (CMBBE 2019), held on August 14-16, 2019, in New York City, USA. It reports on cutting-edge models and algorithms for studying various tissues and organs in normal and pathological conditions; innovative imaging and visualization techniques; and the latest diagnostic tools. Further topics addressed include: numerical methods, machine learning approaches, FEM models, and high-resolution imaging and real-time visualization methods applied for biomedical purposes. Given the scope of its coverage, the book provides graduate students and researchers with a timely and insightful snapshot of the latest research and current challenges in biomedical engineering, computational biomechanics and biological imaging, as well as a source of inspiration for future research and cross-disciplinary collaborations.

✦ Table of Contents

Preface
Contents
About the Editors
Reduced-Order Models for Blood Pressure Drop Across Arterial Stenoses
1 Introduction
2 Fluid Models for Transstenotic Pressure Drop
2.1 The Navier-Stokes Equations
2.2 Long-Wavelength Simplification
2.3 One-Dimensional Model
2.4 Algebraic Model
3 Comparison of the Models on a Steady Case
3.1 Geometry of the Stenosed Artery
3.2 Numerical Methods
3.3 Comparison of the Center Pressure
3.4 Comparison of the Pressure Drop
4 Comparison Between Algebraic and 1D Models Under Unsteady Flow
4.1 Description of the 1D Model
4.2 Parameter Estimation Method
4.3 Estimation of Empirical Parameters on the 1D Model
4.4 Comparison Between Algebraic and 1D Models
5 Comparison Between Algebraic and Multi-Ring Models Under Unsteady Flow
6 Conclusion
References
Impacts of Flow Diverters on Hemodynamics of Intracranial Aneurysms
1 Introduction
2 Materials and Methods
2.1 Patient-Specific Data
2.2 Numerical Methods
2.3 Simulation Setup
3 Results
4 Discussions
5 Conclusions
References
Hypertrophic Cardiomyopathy Treatment – A Numerical Study
Abstract
1 Introduction
2 Methods
2.1 Study Overview
2.2 Geometry and Boundary Conditions
2.3 The Mathematical Model
2.4 The Numerical Model
2.5 Cases Studied and Investigated Parameters
3 Results
3.1 Structure Simulation
3.2 CFD Simulation
4 Discussions and Summary
Acknowledgements
References
Computational Assessment of Risk of Subdural Hematoma Associated with Ventriculoperitoneal Shunt Placement
1 Introduction
2 Methods
2.1 Head Model
2.2 Smoothed Particle Hydrodynamics Formulation
2.3 Computer Simulations
2.4 Simulating Normal-Pressure Hydrocephalus
2.5 Simulating Cerebrospinal Fluid Drainage
2.6 Bridging Veins
3 Results
4 Conclusion
References
Ligament Shear Wave Speeds Are Sensitive to Tensiometer-Tissue Interactions: A Parametric Modeling Study
Abstract
1 Introduction
2 Materials and Methods
2.1 Model Geometry
2.2 Constitutive Model
2.3 Code Verification
2.4 Model Boundary Conditions
2.5 Parametric Modeling and Analysis
3 Results
4 Discussion
4.1 Key Findings
4.2 Applications and Future Directions
4.3 Conclusion
Acknowledgements
A Appendix
A.1 Mesh Convergence
References
Computational Parametric Studies for Preclinical Evaluation of Total Knee Replacements
Abstract
1 Introduction
2 Computational Framework Development
2.1 Analytical Wear Model Development from Experimental Data
2.2 TKR FEA Contact and Wear Model
2.3 Development of a Computational Framework for Parametric Evaluation of TKR Wear
3 Validation of the Wear and FEA Models
3.1 Validation Against Pin-on-Disk Experiments
3.2 Comparison of FEA Wear Prediction to Knee Simulator Tests
4 Verification and Application of the Framework
4.1 Parametric Study of Internal/External Rotation of Tibial Component
4.2 Parametric Study on Sensitivity of Wear to Center of Rotation
5 Discussion
Acknowledgements
References
Poromechanical Modeling of Porcine Knee Joint Using Indentation Map of Articular Cartilage
Abstract
1 Introduction
2 Methods
2.1 3D Reconstruction of Porcine Knee Joints
2.2 Indentation Testing on Intact Articular Cartilage
2.3 Acquisition of Site-Specific Mechanical Properties from the Indentation Data
2.4 Finite Element Simulation of the Knee Joint
3 Results
4 Discussion
Acknowledgments
References
Precise Mean Axis of Rotation (MAR) Analysis for Clinical and Research Applications
Abstract
1 Introduction
2 Methods
2.1 Step 1 - Initial Trace of X-Rays
2.2 Step 2 - Trace Quality Assurance
2.3 Step 3 - Construction of the MAR
2.4 Step 4 - Normalization
3 Results
3.1 Comparing User Traces
3.2 Validating MAR Datasets
3.3 Interobserver Differences and Relative Variance in MAR Dataset
4 Conclusion
References
A Preliminary Sensitivity Study of Vertebral Tethering Configurations Using a Patient-Specific Finite Element Model of Idiopathic Scoliosis
Abstract
1 Introduction
2 Methods
2.1 FEM Details
2.2 Predicted Load-Related Modulation of Vertebral Growth Rate
3 Results
4 Discussion
References
Transpositions of Intervertebral Centroids in Adolescents Suffering from Idiopathic Scoliosis Optically Diagnosed
Abstract
1 Introduction
2 Materials and Methods
3 Results
3.1 Case Studies
4 Conclusion
Acknowledgments
References
Mechano-Physiological Modeling to Probe the Role of Satellite Cells and Fibroblasts in Cerebral Palsy Muscle Degeneration
Abstract
1 Introduction
1.1 Muscle Growth and Regeneration
1.2 Regenerative Potential
1.3 Agent-Based Modeling
2 Methodology
2.1 Construction of an Agent-Based Model for Healthy Muscle Regeneration
3 Results
4 Discussion
5 Conclusions
6 Future Work
References
Deep Learning-Based Segmentation of Mineralized Cartilage and Bone in High-Resolution Micro-CT Images
1 Introduction
2 Materials and Methods
2.1 Data Acquisition, Annotation and Preprocessing
2.2 Network Architecture
2.3 Learning Strategies
2.4 Performance Assessment
3 Results and Discussion
3.1 Quantitative Comparison of the Learning Strategies
3.2 Qualitative Impact of the 3D Consistency
3.3 Qualitative Impact of a Reduction in the Spatial Image Resolution
4 Conclusion and Future Perspectives
References
Statistical Finite Element Analysis of the Mechanical Response of the Intact Human Femur Using a Wide Range of Individual Anatomies
Abstract
1 Introduction
2 Materials and Methods
2.1 Reference Load Configuration
2.2 Optimised Load Configuration: Minimising Reaction Forces
2.3 Comparison Between Reference and Optimised Load Configuration
3 Results
3.1 Reference Load Configuration
3.2 Optimised Load Configuration
4 Discussions
Conflict of Interest
References
Shrinking Window Optimization Algorithm Applied to Pneumatic Artificial Muscle Position Control
1 Introduction
2 The Shrinking Window Algorithm
2.1 Implementation
3 Optimization on Synthetic Benchmark Functions
4 PAM Optimal Control
5 Conclusions
References
Aging Health Behind an Image: Quantifying Sarcopenia and Associated Risk Factors from Advanced CT Analysis and Machine Learning Technologies
Abstract
1 Introduction
2 Materials and Methods
2.1 AGES-Reykjavik Database – NTRA Parameters
2.2 Machine Learning Regression Algorithms
2.3 Regression
2.4 Cross-Validation – k_Fold
2.5 Methodology
3 Results
4 Discussion and Conclusions
Conflict of Interest Declaration
References
Toward a Patient-Specific Image Data-Driven Predictive Modeling Framework for Guiding Microwave Ablative Therapy
Abstract
1 Introduction
1.1 Clinical Background
1.2 Scientific Premise
2 Methods
2.1 Correcting for Intra-procedural Deformations
2.2 Forecasting Intra-procedural Microwave Thermal Dose
2.3 Experimental Procedure
3 Results
4 Discussion
5 Conclusions
Acknowledgements
References
Biomechanical Stress Changes on Forefoot and Hindfoot Caused by the Medializing Calcaneal Osteotomy as Adult Acquired Flatfoot Deformity Treatment
Abstract
1 Introduction
2 Methods
2.1 FE Foot Model and Modifications
2.2 Meshing
2.3 Tissue Properties
2.4 Loading and Boundary Conditions
2.5 About Model Validation
2.6 Model Analysis and Evaluation Criteria
3 Results
3.1 About Model Validation
3.2 Stress in Forefoot Bones Generated by MCO
3.3 Stress in Hindfoot Bones Generated by MCO
4 Discussion
5 Conclusions
References
The Role of Physiological Loading on Bone Fracture Healing Under Ilizarov Circular Fixator: The Effects of Load Duration and Loading Frequency
Abstract
1 Introduction
2 Materials and Methods
2.1 Parametric Study
3 Results and Discussion
3.1 Changes in the Spatial Distribution of the Cells and Growth Factors
3.2 Temporal Changes in the Cell and GF Concentrations Within the Callus
3.3 Summary
3.4 Limitations
4 Conclusions
References
The Effect of Discretization on Parameter Identification. Application to Patient-Specific Simulations
1 Introduction and Related Work
2 Methodology
2.1 Finite-Element Modeling
2.2 Identification Method
3 Results
3.1 Estimated Stiffness
3.2 Shape Error
4 Discussion
References
Local Stiffness Estimation of the Human Eardrum via the Virtual Fields Method
1 Introduction
2 Theory
2.1 Statement of the Principle of Virtual Work
2.2 Assumptions
2.3 Transformation of Coordinates
2.4 Development of the Virtual Fields
2.5 Methodology
3 Results
4 Conclusions
References
Limits of Dynamic Postural Stability with a Segmented Foot Model
Abstract
1 Introduction
2 Human Posture Model with Segmented Feet
2.1 Standing Posture Model in Sagittal Plane
2.2 Segmented Foot Model
3 Multimodal Foot-Ground Contact Interaction
3.1 Foot-Ground Contact Modes Description
3.2 Continuous Model for Contact Modes Transition
4 Limits of Dynamic Postural Stability
5 Results and Discussion
Acknowledgment
References
Optimization of the Kinematic Chain of the Thumb for a Hand Prosthesis Based on the Kapandji Opposition Test
Abstract
1 Introduction
2 Materials and Methods
2.1 IMMA Hand
2.2 Computational Model
2.3 Case Study: Optimization of the TKC of the IMMA Hand
3 Results
4 Discussion
5 Conclusion
Acknowledgments
References
Mathematical Model of Age-Specific Tendon Healing
Abstract
1 Introduction
2 Methods
2.1 Experimental Data
2.2 Models
2.3 Deterministic and Bayesian Approach to Inference
3 Results
3.1 Deterministic Inference
3.2 Bayesian Inference
4 Discussion and Conclusion
Acknowledgments
References
Inception of Material Instabilities in Arteries
1 Introduction
2 Constitutive Theory
3 Strong Ellipticity Condition
4 Specialization of Material
5 Results and Discussion
References
Modelling of Abdominal Wall Under Uncertainty of Material Properties
1 Introduction
2 Materials and Methods
2.1 Finite Element Model of Abdominal Wall
2.2 Constitutive Modelling
2.3 Uncertainty Quantification and Sensitivity Analysis
3 Results
4 Conclusions
References
Fatigue and Wear Analysis for Temporomandibular Joint Prosthesis by Finite Element Method
1 Introduction
2 Materials and Methods
2.1 Static Finite Element Model
2.2 Fatigue Model
2.3 Wear
3 Results
3.1 Static Structural Model
3.2 Fatigue
3.3 Wear Simulation
4 Discussion
References
Connection Between Gait and Balance Functions in Pediatric Patients with Either Neurological or Sensory Integration Problems
1 Introduction
2 Materials and Methods
2.1 Patients
2.2 Methods
3 Results
4 Discussion
References
Classification of Elderly Fallers and Non-fallers Using Force Plate Parameters from Gait and Balance Tasks
Abstract
1 Introduction
2 Methods
2.1 Participants
2.2 Instrumentation
2.3 Experimental Protocol
2.4 Data Analysis
3 Results
4 Discussion
5 Conclusion
References
Accuracy of Anthropometric Measurements by a Video-Based 3D Modelling Technique
Abstract
1 Introduction
2 Method
2.1 Participants
2.2 Manual Anthropometric Measurement
2.3 Anthropometric Measurement with 3D Modelling Techniques
2.4 Statistical Analysis
3 Results
4 Discussions
References
Biomechanical Model for Dynamic Analysis of the Human Gait
Abstract
1 Introduction
2 Methods
2.1 Subjects
2.2 Experimental Setup
2.3 Development of the Biomechanical Model
3 Results
3.1 Kinematic and Kinematic Data
3.2 Biomechanical Model
4 Conclusion
Acknowledgements
References
The Effect of Non-linear Spring-Loaded Knee Orthosis on Lower Extremity Biomechanics
Abstract
1 Introduction
2 Methods
2.1 Trial Movement
2.2 Subject
2.3 Non-linear Spring-Loaded Knee Joint Orthosis
2.4 Measured Kinematic and Kinetic Data
2.5 Three-Dimensional Musculoskeletal Modeling: OpenSim
2.6 Inverse Analysis: Pipeline SimTrack
3 Results
3.1 Knee Joint Angles
3.2 Residual Errors
3.3 Muscle Force
4 Electromyographic Response
5 Discussion
References
Evaluation of a 1-DOF Hand Exoskeleton for Neuromuscular Rehabilitation
Abstract
1 Introduction
2 Methods
2.1 The 1-DOF Exoskeleton and Hand Model
2.2 Admittance Control Paradigm
2.3 Simulation Methods
2.4 Experimental Data Collection
3 Results and Discussion
3.1 Experimental Data of Passive Exoskeleton
3.2 Simulation Results
4 Conclusion
Ethical Approval:
References
Recursive Filtering of Kinetic and Kinematic Data for Center of Mass and Angular Momentum Derivative Estimation
Abstract
1 Introduction
1.1 State of the Art
1.2 Contribution
2 Estimation Algorithm
2.1 Estimated Variables Coupling
2.2 Measurements
2.3 Multi-source Estimation of the CoM Position
2.4 Multi-source Estimation of the Derivative of Angular Momentum
2.5 Recursive Estimation of the CoM Position and of Derivative of Angular Momentum
3 Experimental Validation of the Estimation Framework
3.1 Generation of Ground-Truth and Noisy Measures in Simulation
3.2 Application to Human Data
4 Conclusion
References
An Index Finger Musculoskeletal Dynamic Model
1 Introduction
1.1 Skeletal Dynamics
1.2 Musculotendon Dynamics
1.3 Muscle Activation
1.4 Contribution
2 Methods
2.1 Skeletal Kinematic Model
2.2 Skeletal Dynamic Model
2.3 Musculotendon Kinematic Model
2.4 Musculotendon Dynamic Model
2.5 Muscle Activation Estimation
3 Results and Discussion
3.1 Skeletal Dynamic Model
3.2 Musculotendon Dynamic Model
4 Conclusion
A State-of-the-Art of Muscle Modelling Parameters
References
4D Point Cloud Registration for Tumor Vascular Networks Monitoring from Ultrasensitive Doppler Images
1 Introduction
1.1 Context
1.2 Motivations
2 Material and Mathematical Background
2.1 Material
2.2 Rigid Point Cloud Registration
2.3 Deformable Models
3 Methods and Results
3.1 Rigid Initialization
3.2 Non-linear Registration
3.3 3D Reconstruction of Tumor Growth
4 Conclusion
References
Knee Medial and Lateral Contact Forces Computed Along Subject-Specific Contact Point Trajectories of Healthy Volunteers and Osteoarthritic Patients
Abstract
1 Introduction
2 Materials and Methods
3 Results
3.1 Contact Point Trajectories and Contact Forces
3.2 Linear Regressions
4 Discussion
5 Conclusion
Acknowledgments
References
Consideration of Structural Behaviour of Bones in a Musculoskeletal Simulation Model
1 Introduction
2 Methods
2.1 Simulation Model
2.2 Bone Model
2.3 Hard Landing on the Forearm
2.4 Numerical Solution
3 Results
4 Discussion
5 Conclusion
References
Biomechanical Assessment of the Iris in Relation to Angle-Closure Glaucoma: A Multi-scale Computational Approach
1 Introduction
2 Methods and Materials
3 Results
4 Discussion
5 Conclusions
References
Representative Knee Kinematic Patterns Identification Using Within-Subject Variability Analysis
1 Introduction
2 Related Work
3 Methods
3.1 Data Collection
3.2 Kinematic Data Pre-processing
3.3 Pattern Validation Using Within-Subject Analyzes
4 Results
5 Discussion and Conclusion
References
Towards Particle Tracking Velocimetry of Cell Flow in Developing Tissue Using Deep Neural Network
1 Introduction
2 Method and Model
2.1 Method
2.2 Deep Neural Network Models
3 Results
4 Concluding Remarks
References
Nanoindentation of Subchondral Bone During Osteoarthritis Pathological Process Using Atomic Force Microscopy
Abstract
1 Introduction
2 Materials and Methods
2.1 Murine OA Model
2.2 Analysis of Bone Biomechanics
3 Results
4 Discussion
5 Conclusion
Ethical Approval
References
Computational Modeling of Blood Flow with Rare Cell in a Microbifurcation
1 Introduction
2 Computational Model
2.1 Implementation
3 Simulation Setup
3.1 Geometry
3.2 Cells and Fluid
4 Results
4.1 Red Blood Cell Distributions
4.2 Forces Acting on Cells
5 Conclusion
References
Chondrocyte and Pericellular Matrix Deformation and Strain in the Growth Plate Cartilage Reserve Zone Under Compressive Loading
Abstract
1 Introduction
2 Method
2.1 Model Description
2.2 Stress-Strain Measurement
3 Results
3.1 Influence of Cell Location in the Reserve Zone on Chondrocyte Stress and Strain
3.2 Influence of the Pericellular Matrix on Chondrocyte Stress and Strain
4 Discussion
References
Finite Element Simulations for Investigating the Cause of Catastrophic Wear and/or Failure of Polyethylene Acetabular Cup Liner in Hip Prosthesis
Abstract
1 Introduction
2 Materials and Methods
3 Results
4 Discussion
5 Conclusion
Acknowledgements
References
Constitutive Modelling of Knitted Abdominal Implants in Numerical Simulations of Repaired Hernia Mechanics
Abstract
1 Introduction
2 Materials and Methods
2.1 The Implant
2.2 Constitutive Models
2.3 Description of the Experiments
2.4 Numerical Models and Simulation
3 Results
3.1 Parameters of the Constitutive Models
3.2 Numerical Simulations Results
4 Discussion and Conclusion
Acknowledgments
References
A Novel Image Reconstruction Method in Three Dimensions
Abstract
1 Introduction
2 Image Reconstruction Methodology
3 Numerical Implementation and Examples
4 Conclusions
References
CFD Analysis of Flow Around a Serrated Feather
Abstract
1 Introduction
2 Feather and Calculation Model
2.1 Feather Model
2.2 CFD Method
3 Calculated Results and Discussion
4 Conclusions
References
Fluid-Structure Interaction Modeling of Genetically Engineered Micro-calcification at the Luminal Surface of the Aorta in Mice
Abstract
1 Introduction
2 Materials and Methods
2.1 Geometry Data Acquisition of TNAP Mouse Abdominal Aorta
3 FSI Model and Results
4 Discussion
Compliance with Ethical Standards
References
Experimental Evaluation of Pad Degradation of Helmet for American Football and Its Application to Numerical Design
Abstract
1 Introduction
2 Experimental Evaluation of Helmet Pad
2.1 Pad Foam of American Football Helmets
3 Numerical Analysis
3.1 Head and Helmet Model
3.2 Collision Analysis Model of Head and Helmet
4 Conclusion
References
Creation of Categorical Mandible Atlas to Benefit Non-Rigid Registration
1 Introduction
1.1 Characteristics
1.2 Statistical Shape Modeling
1.3 Nonrigid Registration
2 Methods
2.1 Data Acquisition
2.2 Template Creation
2.3 Registration Testing
2.4 Evaluation Methods
3 Results
4 Discussion
References
3D Constitutive Model of the Rat Large Intestine: Estimation of the Material Parameters of the Single Layers
Abstract
1 Introduction
2 Materials and Methods
3 Results
4 Discussion and Conclusion
References
Differences Between Static and Dynamical Optimization Methods in Musculoskeletal Modeling Estimations to Study Elite Athletes
Abstract
1 Introduction
2 Methods
3 Results
4 Discussion
5 Conclusions
Acknowledgments
References
Dynamical Rheological Properties of In-Silico Epithelial Tissue by Vertex Models
Abstract
1 Introduction
2 Rheology and Complex Modulus
3 Numerical Analysis of In-Silico Epithelial Tissues by Mathematical Models
3.1 Vertex Model
3.2 Bubbly Vertex Model
3.3 Analysis Method and Initial Conditions
4 Results and Discussion
5 Conclusion
Acknowledgments
References
Male Sphincter-Urinary System Behavior Under a Valsalva Maneuver
1 Introduction
2 FEM Model Development
2.1 Mechanical Properties
3 Simulation
4 Results and Discussion
References
Virtual Reality Tools Applied to the Male Urinary System: Visualization and Interaction
1 Introduction
2 Methodology
3 Results
4 Discussion
References
Author Index