Computer control of the penicillin fermentation using the filtration probe in conjunction with a structured process model
✍ Scribed by Eirik Nestaas; Daniel I. C. Wang
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 183 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0006-3592
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A structured model for the penicillin fermentation is presented. This model includes three different cell types: 1) hyphae tips, 2) penicillin‐producing cells, and 3) degenerated, matabolically inactive cells. Cell degeneration has been described previously as a gradual loss of cytoplasmic material by endogenous metabolism. The rate at which such loss of cytoplasm (and activity) proceeds can be expressed as a linear function of the specific growth rate. At growth rates above some minimum value (0.0115 h^−1^) cell degeneration can be prevented. This model served as the control basis during open‐loop as well as closed‐loop computer control of the fermentation. Closed‐loop control was achieved through feedback information of biomass concentration using a filtration probe and was required when complex nutrients contributed significantly to the overall biomass production. © 2006 Wiley Periodicals, Inc.