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Computer-aided selection and optimization of chromatographic columns and conditions for multicolumn analysis procedures

✍ Scribed by Villalobos, Richard ;Annino, Raymond

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
869 KB
Volume
13
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

Clearly, the usefulness of a computer‐aided column design program will depend on its ability to predict quickly and accurately, a design which will yield chromatograms closely approximating those obtained experimentally. Such a computer model for designing and specifying operating conditions for optimum performance of either single or serially coupled columns with different stationary phases is described herein. Tests have been performed in order to verify the accuracy of the model.

In addition to single column optimization and the design of column combinations which can be used to achieve separations difficult or impossible on a single phase alone, the model has proven quite useful as an aid to the design and development of multicolumn analysis procedures that involve critical timing of valve‐switching sequences.

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