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Computer-aided rational design of the phosphotransferase system for enhanced glucose uptake in Escherichia coli

✍ Scribed by Yousuke Nishio; Yoshihiro Usuda; Kazuhiko Matsui; Hiroyuki Kurata

Book ID: 118472687
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 85 KB
Volume: 136
Category: Article
ISSN: 0168-1656
DOI: 10.1016/j.jbiotec.2008.07.043

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## Abstract Overflow metabolism is an undesirable characteristic of aerobic cultures of __Escherichia coli__. It results from elevated glucose consumption rates that cause a high substrate conversion to acetate, severely affecting cell physiology and bioprocess performance. Such phenomenon typicall