𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Computer-aided long-term anticoagulation therapy

✍ Scribed by Lewis B. Sheiner

Publisher
Elsevier Science
Year
1969
Tongue
English
Weight
807 KB
Volume
2
Category
Article
ISSN
0010-4809

No coin nor oath required. For personal study only.

✦ Synopsis

A computer program is described which calculates a suggested daily anticoagulant dose schedule for a patient. The program requires previous prothrombin times and drug dosages as well as physician determined therapeutic goals and limits. A simple compartmental response model is used to predict prothrombin time responses from previous drug doses. Suitable future dose suggestions are calculated from these prothrombin time predictions. A retrospective study provided a test of the program's performance relative to that of resident physicians and three staff cardiologists at a large teaching hospital. The doses computed by the program were found to compare favorably with those of the pilot sample of physicians.

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