The ability of computational methods to describe the relative energies of polymorphic pharmaceuticals is investigated for a diverse array of compounds. The initial molecular geometries were taken from crystal structures, and energy differences between polymorphic pairs were calculated with various g
Computer-aided evaluation of the relative stability of Vaccinium myrtillus anthocyanins
β Scribed by E.M. Martinelli; A. Scilingo; G. Pifferi
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 411 KB
- Volume
- 259
- Category
- Article
- ISSN
- 0003-2670
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β¦ Synopsis
Purified extract of Vaccmtum myrtrllus containing fifteen different anthocyanms was subJected to various amblent conditions m the sohd state and m mild and strong acid solution m order to force the degradation of these pharmacologically active components hqmd chromatographlc analyses of the samples showed that the degradation of the anthocyamns under drastic condltlons (7 days at 100Β°C and 15 days at WC, pH 1 5) dtd not produce important changes m the relative anthocyamn composition Under these conditions only the elgenvector proJection statIstica method can show preferential degradation of anthocyanm arabmosldes m comparison with galactosldes and, to a lesser extent, with glucosldes Mild condltlons (solid samples exposed for 15 days m au and daylight or 15 days at 50Β°C) did not produce significant degradation of the anthocyanms
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