Computer-aided analysis of chromosomal aberrations occurring in an abnormal human karyotype
β Scribed by S. Hazout; A. M. Venuat; A. -J. Valleron; C. Rosenfeld
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 785 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0340-6717
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β¦ Synopsis
A semi-automatic method for recognition of chromosomal changes is presented: from a coded description of an abnormal chromosome (formulated with the aid of an R-banding technique), a computer program makes simulations to reconstitute this chromosomal image from a group of normal chromosomes. Nine types of aberrations (see text) can thus be recognized and the aggregate structure of a group of abnormal chromosomes occurring in a human karyotype can also be rediscovered.
π SIMILAR VOLUMES
The immortalized, nontumorigenic human breast epithelial cell line HMT-3522 has been used as a model for premalignant and, eventually, malignant development. During cultivation, the karyotype evolution was followed. At an early stage, a very long constant phase showed a near-diploid karyotype, with