Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3′,4,4′,7-flavanpentol
✍ Scribed by Chiara Cappelli; Simona Bronco; Susanna Monti
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 1014 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0899-0042
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The synthesis of 46 derivatives of (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol is reported (Scheme 1 and Fig. 3), and their inhibitory activities toward a-mannosidases from jack bean (B) and almonds (A) are evaluated (Table ). The most-potent inhibitors are (2R,3R,4S)-2-{[([1,1'-biphenyl]-4-ylmet
## Abstract Starting with [^14^C]‐D‐tyrosine, carbon‐14 labeled JDTic dihydrochloride with specific activity 15 mCi/mol was prepared in 5% radiochemical yield. Separation of the (3__R__)‐ and (3__S__)‐diastereomers was carried out via the 3‐phenyl‐2,3,10,10a‐tetrahydro‐5H‐imidazo[1,5‐b]isoquinolin‐