Arylpiperazines represent one of the most studied classes of α1 -adrenoceptor (α1 -AR) antagonists. Currently, α1 -AR antagonists are useful in the treatment of benign prostatic hyperplasia, lower urinary tract symptoms or cardiac arrhythmia. The activity of various derivatives of 1-[3-(4-arylpipera
✦ LIBER ✦
Computational studies of the binding site of α1A-adrenoceptor antagonists
✍ Scribed by Minyong Li; Hao Fang; Lupei Du; Lin Xia; Binghe Wang
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 658 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1610-2940
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New compounds selective for α 1A -adrenoceptors in the prostate may offer enhanced efficacy for benign prostatic hyperplasia (BPH), with fewer side effects than current treatment. A-131701 (3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b,hexahydro-[1H]-benz[e]isoindol-2-yl)ethyl]pyrido[3′,4′:4,5]thieno