## Abstract Given the three‐dimensional structure of a protein, how can one find the sites where other molecules might bind to it? Do these sites have the properties necessary for high affinity binding? Is this protein a suitable target for drug design? Here, we discuss recent developments in compu
✦ LIBER ✦
Computational protein design of ligand binding and catalysis
✍ Scribed by Feldmeier, Kaspar; Höcker, Birte
- Book ID
- 121501965
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 418 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1367-5931
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Raman di †erence spectroscopy (RDS) can be employed successfully and generally to overcome the problem of spectral crowding in Raman measurements of large macromolecules, such as proteins. In such an experiment, a protein is "taggedÏ in some way and the di †erence spectrum between the protein and it