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Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2

โœ Scribed by Fang Zheng; Guangrong Zheng; A. Gabriela Deaciuc; Chang-Guo Zhan; Linda P. Dwoskin; Peter A. Crooks


Book ID
118426567
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
403 KB
Volume
15
Category
Article
ISSN
0968-0896

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## Abstract A derivative of tetrabenazine (TBZ, __1__) containing an iodovinyl group (Iโ€TBZ, __3b__) was prepared as a potential radiotracer for the vesicular monoamine transporter. The synthesis of __3a__ was achieved by ethynylation of TBZ. The ethynyl derivative __4__, was converted to the corre