## Abstract Neurogenesis is the process by which cells divide, migrate, and subsequently differentiate into a neuronal phenotype. Significant rates of neurogenesis persist into adulthood in two brain regions, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) of the l
Computational models of adult neurogenesis
โ Scribed by Guillermo A. Cecchi; Marcelo O. Magnasco
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 655 KB
- Volume
- 356
- Category
- Article
- ISSN
- 0378-4371
No coin nor oath required. For personal study only.
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## Abstract The process of neurogenesis continues throughout life, with thousands of new neurons generated every day in the mammalian brain. Impairment of hippocampal neurogenesis has been suggested to be involved in neurodegenerative conditions, including the cognitive decline associated with agin
Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-โค 42 (Aโค 42 )-containing plaques