Optimal methods for meta-analysis of gen
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Baiyu Zhou; Jianxin Shi; Alice S. Whittemore
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Article
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2011
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John Wiley and Sons
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English
β 168 KB
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Meta-analysis of genome-wide association studies involves testing single nucleotide polymorphisms (SNPs) using summary statistics that are weighted sums of site-specific score or Wald statistics. This approach avoids having to pool individual-level data. We describe the weights that maximize the pow