Computational Design and Experimental Testing of the Fastest-Folding β-Sheet Protein
✍ Scribed by Stefano Piana; Krishnarjun Sarkar; Kresten Lindorff-Larsen; Minghao Guo; Martin Gruebele; David E. Shaw
- Book ID
- 116664494
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 617 KB
- Volume
- 405
- Category
- Article
- ISSN
- 0022-2836
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A major bottleneck in the field of biochemistry is our limited understanding of the processes by which a protein folds into its native conformation. Much of the work on this issue has focused on the conserved core of the folded protein. However, one might imagine that a ubiquitous motif for unaided
## Abstract A crucial challenge in present biomedical research is the elucidation of how fundamental processes like protein folding and aggregation occur in the complex environment of the cell. Many new physico‐chemical factors like crowding and confinement must be considered, and immense technical