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Computational de novo Design, and Characterization of an A2B2 Diiron Protein

✍ Scribed by Christopher M Summa; Michael M Rosenblatt; Jae-Kyoung Hong; James D Lear; William F DeGrado

Book ID
117142912
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
843 KB
Volume
321
Category
Article
ISSN
0022-2836

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πŸ“œ SIMILAR VOLUMES

Computer simulations of the properties o
Computer simulations of the properties of the Ξ±2, Ξ±2C, and Ξ±2D de novo designed helical proteins
✍ Andrzej Sikorski; Andrzej Kolinski; Jeffrey Skolnick πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 286 KB πŸ‘ 1 views

Reduced lattice models of the three de novo designed helical proteins ␣ 2 , ␣ 2 C, and ␣ 2 D were studied. Low temperature stable folds were obtained for all three proteins. In all cases, the lowest energy folds were four-helix bundles. The folding pathway is qualitatively the same for all proteins

Characterization of a de novo Designed H
Characterization of a de novo Designed Heme Protein by EPR and ENDOR Spectroscopy
✍ M. Fahnenschmidt; H. K. Rau; R. Bittl; W. Haehnel; W. Lubitz πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 170 KB πŸ‘ 1 views

The binding situation of heme incorporated into a de novo synthesized protein is investigated with EPR and ENDOR spectroscopy. The protein was modeled on the cytochrome b subunit of the cytochrome bc 1 complex and contains two bis-histidine heme binding sites. The EPR spectra show Fe 3 low-spin sign

De Novo Design, Synthesis, and Character
De Novo Design, Synthesis, and Characterization of Quinoproteins
✍ Wen-Wu Li; Petra Hellwig; Michaela Ritter; Wolfgang Haehnel πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 222 KB

## Abstract Quinones and quinoproteins are essential redox components and enzymes in biological systems. Here, we report the de novo design, synthesis, and properties of model four‐α‐helix bundle quinoproteins. The proteins were designed and constructed from three different helices with 21 or 22 am