Computational Bioengineering and Bioinformatics: Computer Modelling in Bioengineering (Learning and Analytics in Intelligent Systems, 11)

✍ Scribed by Nenad Filipovic (editor)

• Publisher: Springer
• Year: 2020
• Tongue: English
• Leaves: 175
• Category: Library

✦ Synopsis

This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

✦ Table of Contents

Contents
Role of Atomic and Molecular Non-observable Properties in the Understanding and Description of Real Observables of the Chemical Systems. A Review
1 Introduction
2 Observables Correlated with Partial Atomic Charges
3 Conclusion
References
Heart Mechanical Model Based on Holzapfel Experiments
1 Introduction
2 Materials and Methods
2.1 Material Model Based on Holzapfel Experiments [1]
2.2 Determination of Stretches in the Material Local Coordinate System
2.3 Determination of Normal Stresses from Current Stretches
2.4 Determination of Shear Stresses from Current Shear Strains
2.5 Compressibility Condition – Penalty Formulation
3 Numerical Examples
3.1 2D Model of Real Heart Wall Segment
4 Summary and Conclusions
References
Finite Element Models with Smeared Fields Within Tissue – A Review of the Current Developments
1 Introduction
2 Smeared Finite Element Model Formulation
3 Coupling Ionic Transport with Electrical Field and Electromechanical Coupling
4 Numerical Examples
4.1 Application of CSFE in Estimation Transport Parameters
4.2 3D Model of Heart Ventricles with Purkinje Fibers, Tissue and Muscle Cells
5 Conclusions
References
Composite Smeared Finite Element – Application to Electrical Field
1 Introduction
2 Smeared Finite Element Model Formulation
3 Conductivity Tensor for Purkinje Network
4 Numerical Examples
4.1 Simple 2D Model
4.2 A Real 2D Model of Heart Wall with Purkinje Fibers
5 Conclusion
References
Application of Composite Smeared Finite Element Model in Drug Delivery Inside Organs
1 Introduction
2 Formulation of the Composite Smeared Finite Element Model
3 Smeared FE Model for Mouse Liver with Tumor
4 Conclusions
References
Tuning Cooperativity of Calcium Activation in Cardiac Muscle
1 Introduction
2 Methods
3 Results and Discussion
4 Conclusions
References
Pre-term Birth Prediction at Home: Signal Filtering Influence on the Good Prediction Rate
1 Introduction
2 Methods
3 Database
4 Results
5 Discussion
6 Conclusions and Perspectives
References
Antioxidative Properties of Usnic Acid and Its Interaction with Tyrosyl-DNA Phosphodiesterase
1 Introduction
2 Theoretical Framework
2.1 Computational Methods
3 Results and Discussion
4 Conclusions
References
Free Radical Scavenger Activity and P-glycoprotein Inhibition Capacity of 1,2,4-Trihydroxyxanthone
1 Introduction
2 Theoretical Framework
3 Computational Details
4 Results and Discussion
4.1 Antioxidative Reaction Mechanisms
4.2 Stability of XA Radicals
4.3 Docking Analysis
5 Conclusions
References
Medical Image Processing Using Xilinx System Generator
1 Introduction
2 Materials and Methods
2.1 Software Co-simulation
2.2 Image Edge Detection
2.3 Thresholding Method
2.4 Hardware Co-simulation
3 Results and Discussion
4 Conclusions
References
Computer Assisted Analysis of the Hepatic Spheroid Formation
1 Introduction
2 Materials
3 Methods
4 Results and Discussion
5 Conclusions and Future Work
References
Investigation of Coumarin Derivative 3-(1-o-toluidinoethylidene)-chromane-2,4-dione: IR Spectroscopic Characterization, NBO, and AIM Analysis and Molecular Docking Studies
1 Introduction
2 Materials and Methods
3 Results and Discussion
4 Conclusions
References
Advanced Modelling Approach of Carotid Artery Atherosclerosis
1 Introduction
2 Related Work
2.1 3D Reconstruction of Arteries
2.2 Computational Simulations of Plague Progression
3 Materials and Methods
3.1 Patient-Specific 3D Models
3.2 Numerical Analysis
4 Results and Discussion
5 Conclusions
References
Effect of Hip Implant Surface Modification on Shear Stress Distribution
1 Introduction
2 Materials and Methods
2.1 Geometries
2.2 Material Properties
2.3 Boundary Conditions
3 Results and Discussion
4 Conclusion
References
Deep Learning Based Approach for Assessment of Primary Sjögren’s Syndrome from Salivary Gland Ultrasonography Images
1 Introduction
2 Instance Segmentation
3 Results
3.1 Dataset Description
3.2 Results on the Salivary Gland Segmentation and pSS Score Prediction Tasks
4 Conclusions
References
Author Index