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Computational analysis of the binding ability of heterocyclic and conformationally constrained epibatidine analogs in the neuronal nicotinic acetylcholine receptor

✍ Scribed by Elena Soriano; José Marco-Contelles; Inés Colmena; Luis Gandía


Publisher
Springer
Year
2009
Tongue
English
Weight
568 KB
Volume
14
Category
Article
ISSN
1381-1991

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## Abstract Based on the crystal structure of the extracellular domain (ECD) of the mouse nicotinic acetylcholine receptor (nAChR) alpha1 subunit bound to α‐bungarotoxin (α‐Btx) we have generated __in silico__ models of the human nAChR α1 bound to α‐Btx and α‐cobratoxin (α‐Cbtx), both in the presen