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Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?

✍ Scribed by Andrew D Lawrence; Andrew H Evans; Andrew J Lees


Book ID
114407505
Publisher
The Lancet
Year
2003
Tongue
English
Weight
226 KB
Volume
2
Category
Article
ISSN
1474-4465

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Compulsive use of dopaminergic drug ther
✍ Andrew H. Evans; Andrew D. Lawrence; Silke Appel Cresswell; Regina Katzenschlage πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 108 KB

A few Parkinson patients develop a disabling pattern of compulsive dopaminergic drug use (''dopamine dysregulation syndrome''-DDS). DDS patients commonly identify aversive dysphoric ''OFF'' mood-states as a primary motivation to compulsively use their drugs. We compared motoric, affective, nonmotor