𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency

✍ Scribed by L. Henneman; M. S. Schneiders; M. Turkenburg; H. R. Waterham


Book ID
106374649
Publisher
Springer
Year
2010
Tongue
English
Weight
180 KB
Volume
33
Category
Article
ISSN
0141-8955

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Manipulation of isoprenoid biosynthesis
✍ Marit S. Schneiders; Sander M. Houten; Marjolein Turkenburg; Ronald J. A. Wander πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 170 KB

## Abstract ## Objective In cells from patients with the autoinflammatory disorder mevalonate kinase (MK) deficiency, which includes the hyperimmunoglobulin D with periodic fever syndrome, MK becomes the rate‐limiting enzyme in the isoprenoid biosynthesis pathway. This suggests that up‐regulation

c-Jun kinase mediates expression of VEGF
✍ M. Luisa SanΓ­ger; Ricardo Oya; David MacΓ­as; Jorge N. DomΓ­nguez; Amelia ArΓ‘nega; πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 324 KB

## Abstract Tumour angiogenesis is mediated by increased levels of vascular endothelial growth factor (VEGF). We have studied the mechanism by which endogenous activation of Rho oncoproteins regulates VEGF expression in COS‐7 and NIH3T3 cells. We carried out transient and stable transfection with c