Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines
β Scribed by Kyunghee Burkitt; Mats Ljungman
- Book ID
- 116334405
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 378 KB
- Volume
- 253
- Category
- Article
- ISSN
- 0304-3835
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π SIMILAR VOLUMES
Cisplatin is a widely used chemotherapeutic agent in head and neck squamous cell carcinoma (HNSCC). Resistance to cisplatin is a common feature of HNSCC. To identify genes that may regulate cisplatin sensitivity, we carried out a cDNA microarray analysis of gene expression in cisplatin-sensitive and
## Abstract ## Background Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). Tools to predict the clinical outcome and evaluate intrinsic cisplatin sensitivity are, therefore, required. ## Methods Cisplatin sensitivity, lysosom