## Abstract Compliance mismatch between the synthetic graft and the surrounding native tissue has been reported as a major factor in ultimate failure of the currently used cardiovascular graft replacements. Thus, developing biomaterials that display close mechanical properties as the tissue it is r
Compression properties of polyvinyl alcohol – bacterial cellulose nanocomposite
✍ Scribed by Leonardo E. Millon; Christine J. Oates; Wankei Wan
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 199 KB
- Volume
- 90B
- Category
- Article
- ISSN
- 1552-4973
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Despite the established use of total joint replacement for the treatment of advanced degeneration of articular cartilage, component loosening due to wear and osteolysis limits the lifespan of these joint prostheses. In the present study, nanocomposites consisting of poly(vinyl alcohol) (PVA) and bacterial cellulose (BC) nanofibers were investigated as possible improved cartilage replacement materials. Nanocomposites were synthesized by adding small amounts (<1%) of BC to PVA, and subjecting the mixture to thermal cycling. The mechanical properties of the resulting material were evaluated using unconfined compression testing. By the addition of BC nanofibers to the PVA matrix, a nanocomposite with a wide range of compressive mechanical properties control was obtained, with elastic modulus values similar to those reported for native articular cartilage. The nanocomposite also showed improved strain‐rate dependence and adequate viscoelastic properties. The PVA–BC nanocomposite is therefore a promising biomaterial to be considered as a possible replacement material for localized articular cartilage injuries and other orthopedic applications such as intervertebral discs. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009
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