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Comprehensive BRCA1 and BRCA2 mutational profile in Lithuania

✍ Scribed by Janavičius, Ramūnas; Rudaitis, Vilius; Mickys, Ugnius; Elsakov, Pavel; Griškevičius, Laimonas


Book ID
122226246
Publisher
Elsevier
Year
2014
Tongue
English
Weight
301 KB
Volume
207
Category
Article
ISSN
2210-7762

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We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie