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Comprehensive Analysis of the Acute Toxicities Induced by Systemic Administration of Cationic Lipid:Plasmid DNA Complexes in Mice

✍ Scribed by Tousignant, Jennifer D.; Gates, Amy L.; Ingram, Laurie A.; Johnson, Carrie L.; Nietupski, Jennifer B.; Cheng, Seng H.; Eastman, Simon J.; Scheule, Ronald K.


Book ID
125534395
Publisher
Mary Ann Liebert
Year
2000
Tongue
English
Weight
424 KB
Volume
11
Category
Article
ISSN
1043-0342

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## Abstract ## Background The type I interferon (IFN) response to DNA/cationic liposome complex, or lipoplex, has been reported in cultured cells, but little is known about the response __in vivo__. Studies of the pro‐inflammatory cytokine response to lipoplex have shown the importance of the unme