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Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

✍ Scribed by Wenfei Wang; Wenzhen Duan; Shuichi Igarashi; Hokuto Morita; Masayuki Nakamura; Christopher A. Ross

Book ID: 116761791
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 492 KB
Volume: 20
Category: Article
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2005.03.026

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## Abstract Patients with Huntington's disease have an expanded polyglutamine tract in huntingtin and suffer severe brain atrophy and neurodegeneration. Because membrane dysfunction can occur in Huntington's disease, we addressed whether mutant huntingtin in brain and primary neurons is present in