Tetrapeptides, as small-sized peptidic i
β
Taeko Kakizawa; Koushi Hidaka; Daisuke Hamada; Ryoji Yamaguchi; Tsuyoshi Uemura;
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Article
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2010
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John Wiley and Sons
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English
β 196 KB
## Abstract Ξ²βSite amyloid precursor protein cleaving enzyme 1 (BACE1) is known to be involved in the production of amyloid Ξ²βpeptide in Alzheimer's disease and is a major target for current drug design. We previously reported substrateβbased peptidomimetics, KMIβcompounds as potent BACE1 inhibitor