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Compound C inhibits hypoxic activation of HIF-1 independent of AMPK

✍ Scribed by Brooke M. Emerling; Benoit Viollet; Kathryn V. Tormos; Navdeep S. Chandel

Book ID: 118442833
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 543 KB
Volume: 581
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2007.11.038

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## Abstract Accumulation of HIF‐1α during normoxic conditions at high cell density has previously been shown to occur and can be used to stabilize HIF‐1α protein in the absence of a specific anaerobic chamber. However, the impact and origin of this pool of HIF‐1α, obtained under normoxia, has been