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Composition of Gangliosides and Neutral Glycosphingolipids of Brain in Classical Tay-Sachs and Sandhoff Disease: More Lyso-GM2 in Sandhoff Disease?

✍ Scribed by Birgitta Rosengren; Jan-Eric Månsson; Lars Svennerholm


Book ID
111174100
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
751 KB
Volume
49
Category
Article
ISSN
0022-3042

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✍ Christine A. Denny; Julie L. Kasperzyk; Kristen N. Gorham; Roderick T. Bronson; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB

## Abstract Caloric restriction (CR), which improves health and increases longevity, was studied as a therapy in a hexosaminidase β knockout mouse model of Sandhoff disease (SD), an incurable neurodegenerative disease involving accumulation of brain ganglioside GM2 and asialo‐GM2 (GA2). Adult mice