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Composite Hodgkin's and Non-Hodgkin's lymphoma in a patient with acquired immune deficiency syndrome. In-situ demonstration of epstein–barr virus

✍ Scribed by Jeannette Guarner; Carlos Del Rio; Lynn Hendrix; Elizabeth R. Unger

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
520 KB
Volume
66
Category
Article
ISSN
0008-543X

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✦ Synopsis

A 44-year-old man infected with human immunodeficiency virus had Hodgkin's disease, mixed cellularity, and malignant non-Hodgkin's lymphoma, diffuse large cell type. Colorimetric in-situ hybridization showed the Epstein-Barr virus (EBV] genome in the cells of the large cell non-Hodgkin's lymphoma and in the Reed-Sternberg cells and reactive lymphocytes of the Hodgkin's lymphoma. These results suggest that EBV may play a similar causative role in both neoplasms. This colorimetric method of hybridization, yielding results within 8 hours, is applicable to archival material and will be useful in further epidemiologic work associating EBV and lymphoid proliferations and malignancies. Cancer 66:796-800, 1990.

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