Complotype genetic loci segregate more frequently with HLA-DR than with HLA-B

✍ Scribed by E. J. Yunis; Z. Awdehl; A. Johnson; N. Suciu-Foca; M.A. Robinson; R. Hartzman; D. Raum; E. leischnicki; C. A. Alper

• Book ID: 104745852
• Publisher: Springer-Verlag
• Year: 1985
• Tongue: English
• Weight: 677 KB
• Volume: 21
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00372238

✦ Synopsis

The loci for BF, C2, C4A, and C4B are very closely linked to each other so that alleles of these plasma protein markers occur in populations in linkage disequilibrium and are inherited as single genetic units called complotypes.

These complotypes are coded by a DNA region of the short arm of chromosome 6 embracing approximately 100 kilobases, which serve as a marker of the major histocompatibility complex. We have studied the complotypes of nine families with known HLA-B/DR crossovers. In seven families, the complotypes were inherited with HLA-DR, including in one family with a double recombination.