𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Compliance issues for the contract manufacturing of cgmp gene therapy products

✍ Scribed by Heide Seitz Webster


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
122 KB
Volume
2
Category
Article
ISSN
1087-8378

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Effect of medium sugar source on the pro
✍ A.S. Coroadinha; J. Ribeiro; A. RoldΓ£o; P.E. Cruz; P.M. Alves; O.-W. Merten; M.J πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 417 KB πŸ‘ 2 views

## Abstract The production of gene therapy retroviral vectors presents many difficulties, mainly due to vector instability and low cell productivities hampering the attainment of high titers of infectious viral vectors. The objective of this work is to increase the production titers of retroviral v

Alkaline-cell lysis through in-line stat
✍ Saethawat Chamsart; Tanyawat Karnjanasorn πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 471 KB πŸ‘ 2 views

## Abstract A state‐of‐the‐art in‐line static mixer reactor (ISMR) was invented to lyse __E. coli__ cells and neutralize the cell lysate continuously and efficiently for the extraction of plasmid DNA. It comprised two connected static dynamic mixers, each 0.01 m in diameter and 0.9 m in length, one

The impact of fluid-dynamic-generated st
✍ S. Chamsart; H. Patel; J. A. J. Hanak; A. G. Hitchcock; A. W. Nienow πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 168 KB πŸ‘ 2 views

## Abstract Extensive tests have been carried out to assess the impact of fluid‐dynamic‐generated stress during alkaline lysis of __Escherichia coli__ cells (host strain DH1 containing the plasmid pTX 0161) to produce a plasmid DNA (pDNA) solution for gene therapy. Both a concentric cylinder rheome