Compliance and tolerability of mefloquine and chloroquine plus proguanil for long-term malaria chemoprophylaxis in groups at particular risk (the military)
✍ Scribed by Mario S. Peragallo; Guido Sabatinelli; Giuseppe Sarnicola
- Book ID
- 104165097
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 657 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0035-9203
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✦ Synopsis
An historical prospective study was performed on 5 120 Italian soldiers deployed in Somalia and Mozambique in 1992-94, to determine compliance and tolerability of long-term malaria chemoprophylaxis with chloroquine plus proguanil (C+P) and with mefloquine. Compliance with C+P among 3734 soldiers on duty in Somalia for 3.8k1.8 months and with mefloquine among 1386 soldiers on duty in Mozambique for 3.4f1.5 months was 90.3% and 957%, respectively (mO.01). Chemoprophylaxis curtailment rate due to side-effects was 1.5% among C+P users and 0.9% among mefloquine users (P=NS). Compliance with chemoprophylaxis and medication curtailment rate due to side-effects did not change significantly for either C+P or mefloquine, even after 3 months of continuous prophylaxis. Chemoprophylaxis curtailment rate was significantly lower in subjects aged 925 years than in older subjects (1.3% vs. 2.5% for C+P [P<O.O5] and 0.4% vs. 3.3% for mefloquine [p<O.Ol]). These results further support the evidence that both C+P and mefloquine regimens may be safely used in long-term malaria chemoprophylaxis. Moreover, weekly mefloquine seems easier to perform than C+P and not to increase prophylaxis discontinuation due to side-effects. Mefloquine regimen should therefore be considered the elective chemoprophylaxis for groups at particular risk of chloroquine-resistant Plasmodium falciparum malaria and especially for young male subjects.