Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation

Coordinated downregulation of the antige

Coordinated downregulation of the antigen presentation machinery and HLA class I/β2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer

✍ Jose María Romero; Pilar Jiménez; Teresa Cabrera; José Manuel Cózar; Susana Pedr 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 327 KB 👁 1 views

Downregulation of MHC class I expression is a widespread phenomenon used by tumor cells to escape antitumor T-cell-mediated immune responses. These alterations may play a role in the clinical course of the disease. The aim of our study was to investigate the molecular mechanism underlying the absenc