𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Complexity analysis of the SAT engine: DNA algorithms as probabilistic algorithms

✍ Scribed by Masami Hagiya; John A. Rose; Ken Komiya; Kensaku Sakamoto


Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
123 KB
Volume
287
Category
Article
ISSN
0304-3975

No coin nor oath required. For personal study only.

✦ Synopsis


Taking advantage of the power of DNA molecules to spontaneously form hairpin structures, Sakamoto et al. designed a molecular algorithm to solve instances of the satisÿability problem on Boolean expressions in clausal form (the SAT problem), and by developing new experimental techniques for molecular biology, they succeeded in solving a 6-variable, 10-clause instance of the 3-SAT problem (Sakamoto et al., Science 288 (2000) 1223). Sakamoto et al. call this computational architecture the SAT Engine. In this paper, we analyze the complexity of the SAT Engine as a probabilistic algorithm. We ÿrst estimate the time dependence of the probability of hairpin formation using standard chemical kinetics and the Jacobson-Stockmayer expression. We then estimate the number of DNA molecules required to solve the satisÿability problem with a given error probability. By taking the number of DNA molecules into account, we ÿnally estimate the minimum total time and number of strands, respectively, required to achieve combined error rates of ¡ 1 (the probability of a false positive) and 2 (the probability of a false negative). If the number of clauses is n, then the time required for solving the problem is proportional to n 1:5 (ln(1= 1) + ln(ln(1= 2))) + n 2:5 ln(3 + ), and the number of necessary DNA molecules is proportional to (3 + ) n ln(1= 2) with arbitrarily small ¿ 0.


📜 SIMILAR VOLUMES


Toward a Generalized Algorithm for the A
✍ F. Castiglione; M. Carravetta; G. Celebre; M. Longeri 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 217 KB

## An existing algorithm, founded on the works of Stephenson and There is a basic difference between the traditional CB-B Binsch, for the automatic analysis of isotropic or simple anisoapproach and automatic analysis programs since, in the fortropic NMR spectra has been improved to treat very comp

Exploring the energy landscapes of molec
✍ Gennady M. Verkhivker; Paul A. Rejto; Daniel K. Gehlhaar; Stephan T. Freer 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 1011 KB

Energy landscapes of molecular recognition are explored by performing "semi-rigid" docking of FK-506 and rapamycin with the Fukisawa binding protein (FKBP-121, and flexible docking simulations of the Ro-31-8959 and AG-1284 inhibitors with HIV-1 protease by a genetic algorithm. The requirements of a