✦ LIBER ✦

Complexities of the Protein Kinase C Pathway

✍ Scribed by Peter M. Blumberg

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 648 KB
Volume: 4
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.2940040502

No coin nor oath required. For personal study only.

✦ Synopsis

Protein kinase C (PKC) has attracted extraordinary research interest over the past decade, resulting in a wealth of information about its structure and function. Our emerging understanding suggests, not surprisingly, that the initial models for activation and function were simplistic and possibly misleading. For those peripherally involved with PKC, this review seeks to highlight areas of controversy.

Abbreviations: PDBu. phorbol-12.13-acetate; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate.

📜 SIMILAR VOLUMES

Activation of the CD3/T cell receptor (T

Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways

✍ Claire Bihoreau; Agnès Heurtier; Alain Enjalbert; Nicole Corvaïa; Armand Bensuss 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 655 KB

Cellular interactions in the thymus regu

Cellular interactions in the thymus regulate the protein kinase C signaling pathway

✍ Helen E. Porritt; Kim L. Anderson; Ravinder K. Suniara; Eric J. Jenkinson; John 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 365 KB 👁 1 views

Polyol pathway and protein kinase C acti

Polyol pathway and protein kinase C activity of rat Schwannoma cells

✍ Hideki Kamiya; Jiro Nakamura; Yoji Hamada; Eitaro Nakashima; Keiko Naruse; Koich 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

## Abstract ## Background Polyol pathway hyperactivity‐induced decreases in protein kinase C (PKC) activities have been proposed as a pathogenic mechanism of diabetic neuropathy. Increased PKC activities have recently been invoked in the pathogenesis of other diabetic complications, especially ret

Induction of protein kinase C down-regul

Induction of protein kinase C down-regulation by the phorbol ester TPA in a calpain/protein kinase C complex

✍ Michel Savart; Pascale Letard; Sandrine Bultel; Andre Ducastaing 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 505 KB

## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo

Differential signalling of purinoceptors

Differential signalling of purinoceptors in HeLa cells through the extracellular signal-regulated kinase and protein kinase C pathways

✍ Antonella Muscella; Simona Greco; Maria Giovanna Elia; Carlo Storelli; Santo Mar 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB 👁 1 views

## Abstract We have previously shown that HeLa cells express P2Y~2~ and P2Y~6~ receptors endogenously and determined the pathways by which the P2Y~2~ controls proliferation and Na^+^/K^+^ATPase activity. Our objective in this study was to investigate the hypothesis that P2Y~6~ also controls prolife

Type I protein kinase C isozyme in the v

Type I protein kinase C isozyme in the visual-information-processing pathway of monkey brain

✍ Freesia L. Huang; Yasuyoshi Yoshida; Hiroki Nakabayashi; David P. Friedman; Lesl 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 710 KB

Previously using PKC isozyme-specific antibodies for immunoblot analysis, we demonstrated the heterogeneous distribution of PKC isozymes in various regions of monkey and rat brains and that type I PKC was most abundant in cerebellum, hippocampus, amygdala, and cerebral cortex (Huang et al.: