Complexes of Group 12 Metal Dihalides with 2-Acetylpyridine-N-oxide 4N-methylthiosemicarbazone (H4MLO). The Crystal Structures and Organization of [Zn(H4MLO)X2] (X = Br, I)
✍ Scribed by Elena Bermejo; Alfonso Castiñeiras; Ricardo Domínguez; Rosa Carballo; Cäcilia Maichle-Mössmer; Joachim Strähle; Anthony E. Liberta; Douglas X. West
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- German
- Weight
- 197 KB
- Volume
- 626
- Category
- Article
- ISSN
- 0372-7874
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✦ Synopsis
Reaction of group 12 metal dihalides with 2-acetylpyridine-N-oxide 4 N-methylthiosemicarbazone (H4MLO) in ethanol afforded compounds [M(H4MLO)X 2 ] (M = Zn II , Cd II , Hg II ; X = Cl, Br, I), the structures of which were characterized by elemental analysis and by IR and 1 H and 13 C NMR spectroscopy. In addition, the complexes of ZnBr 2 and ZnI 2 were analysed structurally by X-ray diffractometry. In [Zn(H4MLO)Br 2 ] the ligand is O,N,S-tridentate and the metal is pentacoordinated, while in [Zn(H4MLO)I 2 ] the thiosemicarbazone is S,O-bis-monodentate and the Zn II ca-tion has a distorted tetrahedral coordination polyhedron. In assays of antifungal activity against Aspergillus niger and Paecilomyces variotii, only the mercury compounds showed any activity, and only [Hg(H4MLO)Cl 2 ] and [Hg(H4MLO)I 2 ] were competitive with nystatin against A. niger.