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Complexes of Escherichia coli adenylate kinase and nucleotides: proton NMR studies of the nucleotide sites in solution

✍ Scribed by Vetter, Ingrid R.; Reinstein, Jochen; Roesch, Paul


Book ID
127276813
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
1008 KB
Volume
29
Category
Article
ISSN
0006-2960

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Site-directed mutagenesis of key amino acids of adenylate kinase has been used to suggest a new model for the location of the AMP and ATP binding sites. Phe-86 and Tyr-133, which are in close contact with the inhibitor Ap5A according to previous crystallographic results, have been independently chan