𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Complexes between some lysine-containing peptides and crown ethers—electrospray ionization mass spectrometric study

✍ Scribed by Rafał Frański; Grzegorz Schroeder; Wojciech Kamysz; Pawel Niedzialkowski; Tadeusz Ossowski

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
210 KB
Volume
42
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The complexes between lysine‐containing peptides (M) and crown ethers (CEs, 18C6, 15C5, 12C4) have been studied by the electrospray ionization (ESI) mass spectrometry. The maximum number of CEs attached has been found to be the same as that of the alkyl‐amino side chains of lysine and as that of the protons attached. Examination of the breakdown plots of the abundances of the ions observed against the cone voltage (CV) has shown that mass spectrometric fragmentation pathways of [M + nH + (CE)~n~]^+n^ may involve a loss of a neutral CE molecule as well as protonated one. The decrease in the CE cavity (the use of 12C4 or 15C5 instead of 18C6) leads to a dramatic lowering in the stability of the complexes in the gas phase but not in solution. Attachment of a CE to peptides increases their hydrophobicity, and therefore proceeds with lower efficiency in water than in methanol. Copyright © 2007 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Non-covalent dimers of the lysine contai
Non-covalent dimers of the lysine containing protonated peptide ions in gaseous state: electrospray ionization mass spectrometric study
✍ Shibdas Banerjee; Shyamalava Mazumdar 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB 👁 1 views

## Abstract Study of the non‐covalent molecular complexes in gas phase by electrospray ionization mass spectrometry (ESI‐MS) represents a promising strategy to probe the intrinsic nature of these complexes. ESI‐MS investigation of a series of synthetic octapeptides containing six alanine and two ly

Study of non-covalent complexation betwe
Study of non-covalent complexation between catechin derivatives and peptides by electrospray ionization mass spectrometry
✍ Pascale Sarni-Manchado; Véronique Cheynier 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 1 views

The recent development of electrospray ionization mass spectrometry (ESI-MS) has allowed its use to study molecular interactions driven by non-covalent forces. ESI-MS has been used to detect non-covalent complexes between proteins and metals, ligands and peptides and interactions involving DNA, RNA,