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Complexation of the Non-steroidal Anti-inflammatory Drug Nabumetone with Modified and Unmodified Cyclodextrins

✍ Scribed by Margarita Valero; Silvia M. B. Costa; José R. Ascenso; M. Mercedes Velázquez; Licesio J. Rodríguez

Book ID
110257425
Publisher
Springer Netherlands
Year
1999
Tongue
English
Weight
119 KB
Volume
35
Category
Article
ISSN
0923-0750

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✍ Hemant K. Roy; William J. Karolski; Anne Ratashak 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 225 KB

Use of non-steroidal anti-inflammatory drugs (NSAIDs) for chemoprevention of colon cancer has been hindered by their potential gastro-intestinal toxicity. Nabumetone, which is approximately 10 to 36 times safer than conventional NSAIDs, was evaluated in 2 models of experimental colon carcinogenesis.